CBD or cannabidiol is deprived of psychoactive properties, but it helps with various diseases
Recently, the topic of medical marijuana has been surfacing more and more often in foreign media, scientists are trying their best to get permissions and funding for research in this area, believing in its promise, and in many countries of the world, decriminalization and legalization are underway.
Most hype now causes a substance such as CBD or cannabidiol contained in the hemp plant. Today it can be found anywhere – from food to decorative cosmetics and quite legally purchased in online stores in the form of oil. And all because CBD does not have psychoactive properties, unlike tetrahydrocannabinol (THC), but it has healing properties.
Since CBD is an active component of marijuana itself, you can get profit from it by smoking a joint in the old fashioned way. The main thing is to make sure that a grade with a predominance of this particular substance, rather than THC, is clogged in your joint if you just want to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to control paranoia.
Let’s try to figure out how this magical cannabidiol works, based on the latest data from the world of science and the experience of consumers using CBD as a medicine, and not for fun.
The difference between the effects of CBD and THC
Since cannabidiol is not a psychoactive substance, you can’t get high from it, but it’s easy to increase your productivity, relieve anxiety and relieve pain. When using CBD organic USA, thoughts are not confused, memory does not deteriorate, and as a result of muscle relaxation, you do not become a vegetable, as is often the case with smoking cannabis varieties with a predominance of THC.
If the ratio of these substances is approximately the same, then you will find a slight euphoric and the above-mentioned beneficial effects at the same time. At the same time, such negative consequences as paranoia, dry mouth, drying out and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are often caused by THC, do not occur. Such varieties are most often used as a painkiller.
Although CBD works well alone, some experts still insist that in combination with other active components of marijuana, it brings more benefits:
“To achieve a better therapeutic effect, you need a mix of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not yet say with accuracy. This knowledge gap is caused, first of all, by a lack of research data, since the field of studying the healing properties of hemp is still in its infancy. But the gradual legalization of medical marijuana suggests that scientists will soon have more freedom for their experiments. So hold the fists, hope and believe.
What diseases cannabidiol helps to cope with
Some scientific papers suggest that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope that this substance will help pharmaceutical companies to develop effective drugs against many disorders and diseases accompanied by similar symptoms.
The list of such diseases includes, but is not limited to such pathological conditions:
- Epilepsy and convulsive disorders.
- Various inflammations with severe pain.
- PTSD and anxiety disorder.
- Crohn’s disease.
- Multiple sclerosis.
- Opiate withdrawal syndrome.
So far, there are no full-fledged drugs based on CBD to combat these disorders, but many patients claim that the substance helps them to alleviate and even completely get rid of the symptoms.
Recently in the USA, where marijuana is still on the list of the most dangerous psychoactive substances, there has been a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the first marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant effect of which the FDA has confirmed with its tests. Today, Epidiolex is used to treat severe forms of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there were other drugs based on the components of marijuana. For example, the Belgian company Solvay Pharmaceuticals back in 1985 created Marinol (dronabinol), a medication that is simply a synthetic THC, which is still used today to increase the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal parts of CBD and THC, to relieve muscle cramps and other symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there is still not so much data on how CBD has a beneficial effect on the body, scientists still have some ideas on this subject. Surprisingly, cannabidiol does not bind to the active sites of the cannabinoid receptors CB1 and CB2, as does the same THC. But it interacts with the GPR55 protein secreted in the brain and peripheral organs. Researchers believe that this determines its antispasmodic effect.
In the brain, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted from one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more often than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, according to Ben Wally, head of research at GW Pharmaceuticals.
The relationship of this protein with CBD is confirmed by experiments with genetically modified rodents in which epileptic seizures were caused. Those animals in which GPR55 was present responded to cannabidiol treatment, and rats without protein continued to experience convulsions.
Wally also believes that CBD can contribute to the desensitization of the TRPV1 protein, which is involved in the transport of ions and calcium in the body, which also helps relieve cramping. First, cannabidiol activates this protein, but then quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 do not respond to CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance produced by the body. Wally believes that cannabidiol suppresses seizures, mainly due to its effect on adenosine, but more experiments are needed to confirm this hypothesis.
Such a wide range of areas in which CBD is active allows scientists to suggest that this substance may be useful in the treatment of motor disorders, such as Parkinson’s disease. And the interaction with serotonin receptors suggests that cannabidiol can be used to treat depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as Roger Pertwee, a professor at the University of Aberdeen and the head of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it cannot be confidently stated that the interaction of CBD with these receptors and proteins means that it causes a therapeutic effect of this substance.
Thanks for reading my post; I hope you have got useful information about CBD and THC. Please share your valuable experience with us.